NUU Public Talks 8.0 : Cellular Mechanisms in the Pathogenesis of Neurodegenerative Diseases

Today, on May 2, a scientific seminar was held at the Faculty of Biology and Ecology of the National University of Uzbekistan, organized by the Young Biochemists Club (https://t.me/biokimyogarlarklubi) and the NUU Public Talks club.

The seminar featured a lecture by Professor Andrey Abramov, head of the Laboratory of Clinical and Movement System Pathologies at the Institute of Neurology, University College London (UCL), on the topic “Cellular Mechanisms in the Pathogenesis of Neurodegenerative Diseases.”

In his presentation, Professor Abramov gave a detailed overview of the cellular-level causes of widespread neurodegenerative diseases such as Alzheimer’s and Parkinson’s, discussing their genetic and biochemical foundations and the latest scientific research being conducted in this field.

Today’s scientific approaches identify mitochondrial dysfunction, calcium homeostasis disruption, and pathological accumulation of protein oligomers as key mechanisms of neurodegeneration

The lecture also provided in-depth information on the experiments conducted at the London Institute of Neurology, including methodologies and findings. Students gained a deeper understanding, especially regarding the model organisms used in the study of these diseases.

The seminar addressed important aspects such as genetic mutations, mitochondrial dysfunction, irregular calcium ion regulation, and protein aggregation within cells. It was also noted that these diseases are not limited to developed countries but are becoming increasingly common in Uzbekistan, underlining the need for early diagnosis and intensified research in this area.

At the end of the seminar, participants had the opportunity to ask questions of interest. Discussions were especially lively around statistics related to neurodegenerative diseases in aging populations.

To conclude the event, Raima Shirinova, Vice-Rector for International Relations at the National University of Uzbekistan, expressed sincere gratitude to Professor Andrey Abramov and presented him with a certificate and commemorative gifts.

Master’s students in Biophysics and Biochemistry actively participated in the seminar, enriching their theoretical knowledge with real scientific data. The topic served as a logical extension of their curriculum, helping students gain a comprehensive understanding of the origins and mechanisms of diseases that lead to the death of brain cells.

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